CLEC4A

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C-type lectin domain family 4, member A
Identifiers
Symbols CLEC4A ; CLECSF6; DCIR; DDB27; LLIR
External IDs OMIM605306 MGI1349412 HomoloGene49291 GeneCards: CLEC4A Gene
RNA expression pattern
PBB GE CLEC4A 219947 at tn.png
PBB GE CLEC4A 221724 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50856 26888
Ensembl ENSG00000111729 ENSMUSG00000030148
UniProt Q9UMR7 Q9QZ15
RefSeq (mRNA) NM_016184 NM_001170332
RefSeq (protein) NP_057268 NP_001163803
Location (UCSC) Chr 12:
8.28 – 8.29 Mb
Chr 6:
123.11 – 123.14 Mb
PubMed search [1] [2]

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.[1][2]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[2]

References[edit]

  1. ^ Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol 163 (4): 1973–83. PMID 10438934. 
  2. ^ a b "Entrez Gene: CLEC4A C-type lectin domain family 4, member A". 

Further reading[edit]