C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4Agene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Huang X, Yuan Z, Chen G, et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.". Biochem. Biophys. Res. Commun.281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID11178971.
Richard M, Veilleux P, Rouleau M, et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation.". J. Leukoc. Biol.71 (5): 871–80. PMID11994513.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins53 (1): 44–55. doi:10.1002/prot.10440. PMID12945048.
Richard M, Thibault N, Veilleux P, et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.". Biochem. Biophys. Res. Commun.310 (3): 767–73. doi:10.1016/j.bbrc.2003.09.077. PMID14550269.
Richard M, Thibault N, Veilleux P, et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.". Mol. Immunol.43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID16360206.
Lorentzen JC, Flornes L, Eklöw C, et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors.". Arthritis Rheum.56 (8): 2620–32. doi:10.1002/art.22813. PMID17665455.