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C-type lectin domain family 4, member M
Protein CLEC4M PDB 1k9j.png
PDB rendering based on 1k9j.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605872 MGI2157947 HomoloGene129771 GeneCards: CLEC4M Gene
RNA expression pattern
PBB GE CLEC4M 207995 s at tn.png
PBB GE CLEC4M 210481 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10332 170786
Ensembl ENSG00000104938 ENSMUSG00000031494
UniProt Q9H2X3 Q91ZX1
RefSeq (mRNA) NM_001144904 NM_133238
RefSeq (protein) NP_001138376 NP_573501
Location (UCSC) Chr 19:
7.83 – 7.83 Mb
Chr 8:
3.74 – 3.75 Mb
PubMed search [1] [2]

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.[1] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[2]


  1. ^ Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene 228 (1-2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769. 
  2. ^ "Entrez Gene: CLEC4M C-type lectin domain family 4, member M". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.