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Chloride channel, nucleotide-sensitive, 1A

PDB rendering based on 1zyi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLNS1A ; CLCI; CLNS1B; ICln
External IDs OMIM602158 MGI109638 HomoloGene990 GeneCards: CLNS1A Gene
RNA expression pattern
PBB GE CLNS1A 209143 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1207 12729
Ensembl ENSG00000074201 ENSMUSG00000025439
UniProt P54105 Q923F1
RefSeq (mRNA) NM_001293 NM_023671
RefSeq (protein) NP_001284 NP_076160
Location (UCSC) Chr 11:
77.23 – 77.35 Mb
Chr 7:
97.7 – 97.72 Mb
PubMed search [1] [2]

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.[1][2][3]


CLNS1A has been shown to interact with Small nuclear ribonucleoprotein D1,[4] ITGA2B,[5] SNRPD3[4] and Protein arginine methyltransferase 5.[4][6][7]

See also[edit]


  1. ^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun 208 (1): 89–95. doi:10.1006/bbrc.1995.1309. PMID 7887970. 
  2. ^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725. 
  3. ^ "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A". 
  4. ^ a b c Friesen, W J; Paushkin S, Wyce A, Massenet S, Pesiridis G S, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. (United States) 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. ISSN 0270-7306. PMC 99994. PMID 11713266. 
  5. ^ Larkin, Deirdre; Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. (United States) 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326. 
  6. ^ Krapivinsky, G; Pu W, Wickman K, Krapivinsky L, Clapham D E (May 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. (United States) 273 (18): 10811–4. doi:10.1074/jbc.273.18.10811. ISSN 0021-9258. PMID 9556550. 
  7. ^ Friesen, Westley J; Wyce Anastasia, Paushkin Sergey, Abel Linda, Rappsilber Juri, Mann Matthias, Dreyfuss Gideon (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. (United States) 277 (10): 8243–7. doi:10.1074/jbc.M109984200. ISSN 0021-9258. PMID 11756452. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.