CLTC

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Clathrin, heavy chain (Hc)
Protein CLTC PDB 1b89.png
PDB rendering based on 1b89.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CLTC ; CHC; CHC17; CLH-17; CLTCL2; Hc
External IDs OMIM118955 MGI2388633 HomoloGene3572 GeneCards: CLTC Gene
RNA expression pattern
PBB GE CLTC 200614 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1213 67300
Ensembl ENSG00000141367 ENSMUSG00000047126
UniProt Q00610 Q68FD5
RefSeq (mRNA) NM_004859 NM_001003908
RefSeq (protein) NP_004850 NP_001003908
Location (UCSC) Chr 17:
57.7 – 57.77 Mb
Chr 11:
86.69 – 86.76 Mb
PubMed search [1] [2]

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[1][2]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[3]

Interactions[edit]

CLTC has been shown to interact with PICALM[4] and HGS.[5]

See also[edit]

References[edit]

  1. ^ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375. 
  2. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
  3. ^ "Entrez Gene: CLTC clathrin, heavy chain (Hc)". 
  4. ^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell (UNITED STATES) 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022. 
  5. ^ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. (England) 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.