Activating CMKLR1 by an agonist mobilizes intracellular calcium and causes the activation of several other signaling cascades like the ERK1 and NF-κB. Initial studies of CMKLR1 suggested that it might have a role in the inflammatory pathways. Its cognate ligand, chemerin was found in joint aspirate from rheumatoid arthritis and absent in aspirate from degenerative arthritis. CMKLR1 expression by plasmacytoid dendritic cells and macrophages also helped foster this idea. In vitro chemotaxis assays showed it to be utilized in attracting these cells. As an adipokine receptor it has a role in adipogenesis and adipocyte maturation. It seems also to have a role in peripheral insulin resistance.
^Gantz I, Konda Y, Yang YK, Miller DE, Dierick HA, Yamada T (1996). "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors". Cytogenet. Cell Genet.74 (4): 286–90. doi:10.1159/000134436. PMID8976386.
^Methner A, Hermey G, Schinke B, Hermans-Borgmeyer I (April 1997). "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development". Biochem. Biophys. Res. Commun.233 (2): 336–42. doi:10.1006/bbrc.1997.6455. PMID9144535.
^Kaur J, Adya R, Tan BK, Chen J, Randeva HS (January 2010). "Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis". Biochem. Biophys. Res. Commun.391 (4): 1762–8. doi:10.1016/j.bbrc.2009.12.150. PMID20044979.
^Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ (September 2007). "Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism". J. Biol. Chem.282 (38): 28175–88. doi:10.1074/jbc.M700793200. PMID17635925.
^Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K (March 2008). "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes". FEBS Lett.582 (5): 573–8. doi:10.1016/j.febslet.2008.01.023. PMID18242188.
Mårtensson UE, Fenyö EM, Olde B, Owman C (2006). "Characterization of the human chemerin receptor--ChemR23/CMKLR1--as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains.". Virology355 (1): 6–17. doi:10.1016/j.virol.2006.07.010. PMID16904155.