CMKLR1

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Chemokine-like receptor 1
Identifiers
Symbols CMKLR1 ; CHEMERINR; ChemR23; DEZ; RVER1
External IDs OMIM602351 MGI109603 HomoloGene129967 IUPHAR: CMKLR1 ChEMBL: 3540 GeneCards: CMKLR1 Gene
RNA expression pattern
PBB GE CMKLR1 207652 s at tn.png
PBB GE CMKLR1 210659 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1240 14747
Ensembl ENSG00000174600 ENSMUSG00000042190
UniProt Q99788 P97468
RefSeq (mRNA) NM_001142343 NM_008153
RefSeq (protein) NP_001135815 NP_032179
Location (UCSC) Chr 12:
108.29 – 108.34 Mb
Chr 5:
113.61 – 113.65 Mb
PubMed search [1] [2]

Chemokine receptor-like 1 also known as ChemR23 (Chemerin Receptor 23) is a protein that in humans is encoded by the CMKLR1 gene.[1][2] Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin[3] and the omega-3 fatty acid derived molecule resolvin E1.[4] The murine receptor that shares almost 80% homology with the human receptor, is called Dez.[5]

Tissue distribution[edit]

CMKLR1 shows wide RNA expression profile but is notably high in plasmacytoid dendritic cells, macrophages, cardiomyocytes, adipocytes and endothelial cells.[6]

Function[edit]

Activating CMKLR1 by an agonist mobilizes intracellular calcium and causes the activation of several other signaling cascades like the ERK1 and NF-κB. Initial studies of CMKLR1 suggested that it might have a role in the inflammatory pathways. Its cognate ligand, chemerin was found in joint aspirate from rheumatoid arthritis and absent in aspirate from degenerative arthritis. CMKLR1 expression by plasmacytoid dendritic cells and macrophages also helped foster this idea. In vitro chemotaxis assays showed it to be utilized in attracting these cells. As an adipokine receptor it has a role in adipogenesis and adipocyte maturation.[7] It seems also to have a role in peripheral insulin resistance.[8]

Also studies using the mouse zymosan model and chemerin peptides showed that these peptides suppressed and helped resolve the peritonitis in mice.[9] The same model showed that this particular molecule enhances macrophage efferocytosis (phagocyting apoptotic cells).[10]

References[edit]

  1. ^ "Entrez Gene: CMKLR1 chemokine-like receptor 1". 
  2. ^ Gantz I, Konda Y, Yang YK, Miller DE, Dierick HA, Yamada T (1996). "Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors". Cytogenet. Cell Genet. 74 (4): 286–90. doi:10.1159/000134436. PMID 8976386. 
  3. ^ Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brézillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D (October 2003). "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids". J. Exp. Med. 198 (7): 977–85. doi:10.1084/jem.20030382. PMC 2194212. PMID 14530373. 
  4. ^ Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN (March 2005). "Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1". J. Exp. Med. 201 (5): 713–22. doi:10.1084/jem.20042031. PMC 2212834. PMID 15753205. 
  5. ^ Methner A, Hermey G, Schinke B, Hermans-Borgmeyer I (April 1997). "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development". Biochem. Biophys. Res. Commun. 233 (2): 336–42. doi:10.1006/bbrc.1997.6455. PMID 9144535. 
  6. ^ Kaur J, Adya R, Tan BK, Chen J, Randeva HS (January 2010). "Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis". Biochem. Biophys. Res. Commun. 391 (4): 1762–8. doi:10.1016/j.bbrc.2009.12.150. PMID 20044979. 
  7. ^ Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ (September 2007). "Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism". J. Biol. Chem. 282 (38): 28175–88. doi:10.1074/jbc.M700793200. PMID 17635925. 
  8. ^ Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K (March 2008). "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes". FEBS Lett. 582 (5): 573–8. doi:10.1016/j.febslet.2008.01.023. PMID 18242188. 
  9. ^ Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR (April 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23". J. Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062. 
  10. ^ Cash JL, Christian AR, Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner". J. Immunol. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMID 20363975. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.