CMPK

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Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
Protein CMPK PDB 1tev.png
PDB rendering based on 1tev.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CMPK1 ; CK; CMK; CMPK; UMK; UMP-CMPK; UMPK
External IDs OMIM191710 MGI1913838 HomoloGene32308 ChEMBL: 5681 GeneCards: CMPK1 Gene
EC number 2.7.4.14, 2.7.4.6
RNA expression pattern
PBB GE CMPK 217870 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51727 66588
Ensembl ENSG00000162368 ENSMUSG00000028719
UniProt P30085 Q9DBP5
RefSeq (mRNA) NM_001136140 NM_025647
RefSeq (protein) NP_001129612 NP_079923
Location (UCSC) Chr 1:
47.8 – 47.84 Mb
Chr 4:
114.96 – 114.99 Mb
PubMed search [1] [2]

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.[1][2]

Function[edit]

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[2][3]

References[edit]

  1. ^ Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology 56 (3): 562–9. PMID 10462544. 
  2. ^ a b EntrezGene 51727
  3. ^ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research 62 (6): 1624–31. PMID 11912132. 

Further reading[edit]

  • Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C et al. (1992). "Human liver protein map: A reference database established by microsequencing and gel comparison". Electrophoresis 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD et al. (1993). "Human liver protein map: Update 1993". Electrophoresis 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. 
  • Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region". Life Sciences 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623. 
  • Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research 62 (6): 1624–31. PMID 11912132. 
  • Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". European Journal of Biochemistry 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191. 
  • Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). "Substrate-induced Conformational Changes in Human UMP/CMP Kinase". Journal of Biological Chemistry 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660. 
  • Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium". Molecular Pharmacology 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676. 
  • Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). "Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". Journal of Neurochemistry 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899. 
  • Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA et al. (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site". FEBS Journal 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725. 
  • Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A et al. (2003). "UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity". European Journal of Biochemistry 270 (15): 3196–204. doi:10.1046/j.1432-1033.2003.03702.x. PMID 12869195. 
  • Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H et al. (2007). "Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase". The FEBS journal 274 (13): 3363–73. doi:10.1111/j.1742-4658.2007.05870.x. PMID 17542990.