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CMT may refer to:
- California mastitis test, a simple cow-side indicator of the somatic cell count of milk
- Certified Massage Therapist
- Cervical motion tenderness, a sign of pelvic inflammatory disease
- Charcot–Marie–Tooth disease, a group of disorders of the peripheral nervous system characterised by progressive loss of muscle tissue and touch sensation across various parts of the body
- Chemically modified tetracyclines, a type of tetracycline antibiotics
- Combat Medical Technician
- Canal Maximo Televisión, a defunct Venezuelan regional network
- Castilla-La Mancha TV, a Spanish regional channel
- Country Music Television, a U.S. cable television channel
- CMT (Canada), a Canadian country music television channel
Other uses 
- Cadmium Mercury Telluride
- California Musical Theatre, a nonprofit arts organization in Sacramento, California
- Cambridge Mathematical Tripos, a mathematics course at the University of Cambridge
- Carrier Mortar Tracked, a self-propelled mortar system developed in India
- Chaos Magick Theory, the theoretical basis for chaos magic, espoused by Peter J. Carroll
- Chaconia Medal, one of the awards of the Republic of Trinidad and Tobago
- Chartered Market Technician, a professional designation that confirms proficiency in technical analysis of the financial markets.
- Chip-level multithreading a form of simultaneous multithreading
- Communication, Media and Technology, a Siemens software company.
- Composable Memory Transactions
- Compulsory Military Training
- Confédération Mondiale du Travail or World Confederation of Labour, an international confederation of trade unions
- Connecticut Mastery Test, a test administered to students in grades 3 through 8
- Constant-maturity treasury
- Container Managed Transactions, see Enterprise JavaBeans
- Culturally modified tree, the modification of a tree by indigenous people as part of their tradition
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