CMV polyradiculomyelopathy

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CMV polyradiculomyelopathy (PRAM) is one of the five distinct neurological syndromes caused by CMV in HIV/AIDS. It causes subacute ascending lower extremity weakness with paresthesias and radicular pain, hyporeflexia or areflexia,[1] and urinary retention.[2] It has been suggested that CMV polyradiculomyelopathy should be treated with both ganciclovir and foscarnet in patients who develop the disease while taking either of these drugs.[3]


  1. ^ Cohen, B. A.; McArthur, J. C.; Grohman, S.; Patterson, B.; Glass, J. D. (1 March 1993). "Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS". Neurology 43 (3, Part 1): 493–493. doi:10.1212/WNL.43.3_Part_1.493. 
  2. ^ Guiot, HM; Pita-García, IL; Bertrán-Pasarell, J; Alfonso, G (December 2006). "Cytomegalovirus polyradiculomyelopathy in AIDS: a case report and review of the literature.". Puerto Rico health sciences journal 25 (4): 359–62. PMID 17550105. 
  3. ^ Reiss, Carol (2008). Neurotropic Viral Infections. 355: Cambridge University Press.