CNKSR1

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Connector enhancer of kinase suppressor of Ras 1
Protein CNKSR1 PDB 1wwv.png
PDB rendering based on 1wwv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CNKSR1 ; CNK; CNK1; KSR
External IDs OMIM603272 MGI2670958 HomoloGene4604 GeneCards: CNKSR1 Gene
RNA expression pattern
PBB GE CNKSR1 204740 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10256 194231
Ensembl ENSG00000142675 ENSMUSG00000028841
UniProt Q969H4 A2A9K7
RefSeq (mRNA) NM_006314 NM_001081047
RefSeq (protein) NP_006305 NP_001074516
Location (UCSC) Chr 1:
26.5 – 26.52 Mb
Chr 4:
134.23 – 134.24 Mb
PubMed search [1] [2]

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[1][2]

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[2]

Interactions[edit]

CNKSR1 has been shown to interact with RhoD[3] and RASSF1.[4]

References[edit]

  1. ^ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell 95 (3): 343–53. doi:10.1016/S0092-8674(00)81766-3. PMID 9814705. 
  2. ^ a b "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1". 
  3. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. (United States) 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388. 
  4. ^ Rabizadeh, Shahrooz; Xavier Ramnik J, Ishiguro Kazuhiro, Bernabeortiz Juliocesar, Lopez-Ilasaca Marco, Khokhlatchev Andrei, Mollahan Pamela, Pfeifer Gerd P, Avruch Joseph, Seed Brian (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. (United States) 279 (28): 29247–54. doi:10.1074/jbc.M401699200. ISSN 0021-9258. PMID 15075335. 

Further reading[edit]

External links[edit]