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Connector enhancer of kinase suppressor of Ras 1
Protein CNKSR1 PDB 1wwv.png
PDB rendering based on 1wwv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CNKSR1 ; CNK; CNK1; KSR
External IDs OMIM603272 MGI2670958 HomoloGene4604 GeneCards: CNKSR1 Gene
RNA expression pattern
PBB GE CNKSR1 204740 at tn.png
More reference expression data
Species Human Mouse
Entrez 10256 194231
Ensembl ENSG00000142675 ENSMUSG00000028841
UniProt Q969H4 A2A9K7
RefSeq (mRNA) NM_006314 NM_001081047
RefSeq (protein) NP_006305 NP_001074516
Location (UCSC) Chr 1:
26.5 – 26.52 Mb
Chr 4:
134.23 – 134.24 Mb
PubMed search [1] [2]

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[1][2]

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[2]


CNKSR1 has been shown to interact with RhoD[3] and RASSF1.[4]


  1. ^ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell 95 (3): 343–53. doi:10.1016/S0092-8674(00)81766-3. PMID 9814705. 
  2. ^ a b "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1". 
  3. ^ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. (United States) 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388. 
  4. ^ Rabizadeh, Shahrooz; Xavier Ramnik J, Ishiguro Kazuhiro, Bernabeortiz Juliocesar, Lopez-Ilasaca Marco, Khokhlatchev Andrei, Mollahan Pamela, Pfeifer Gerd P, Avruch Joseph, Seed Brian (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. (United States) 279 (28): 29247–54. doi:10.1074/jbc.M401699200. ISSN 0021-9258. PMID 15075335. 

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