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Contactin 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CNTN1 ; F3; GP135; MYPCN
External IDs OMIM600016 MGI105980 HomoloGene7274 GeneCards: CNTN1 Gene
RNA expression pattern
PBB GE CNTN1 211203 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1272 12805
Ensembl ENSG00000018236 ENSMUSG00000055022
UniProt Q12860 P12960
RefSeq (mRNA) NM_001256063 NM_001159647
RefSeq (protein) NP_001242992 NP_001153119
Location (UCSC) Chr 12:
41.09 – 41.47 Mb
Chr 15:
92.05 – 92.34 Mb
PubMed search [1] [2]

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.[1][2]


The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]


CNTN1 has been shown to interact with PTPRB.[3][4]


  1. ^ Berglund EO, Ranscht B (June 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12". Genomics 21 (3): 571–82. doi:10.1006/geno.1994.1316. PMID 7959734. 
  2. ^ a b "Entrez Gene: CNTN1 contactin 1". 
  3. ^ Sakurai, T; Lustig M; Nativ M; Hemperly J J; Schlessinger J; Peles E; Grumet M (February 1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". J. Cell Biol. (UNITED STATES) 136 (4): 907–18. doi:10.1083/jcb.136.4.907. ISSN 0021-9525. PMC 2132488. PMID 9049255. 
  4. ^ Peles, E; Nativ M, Campbell P L, Sakurai T, Martinez R, Lev S, Clary D O, Schilling J, Barnea G, Plowman G D, Grumet M, Schlessinger J (July 1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell (UNITED STATES) 82 (2): 251–60. doi:10.1016/0092-8674(95)90312-7. ISSN 0092-8674. PMID 7628014. 

Further reading[edit]