COASY

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CoA synthase
Identifiers
Symbols COASY ; DPCK; NBIA6; NBP; PPAT; UKR1; pOV-2
External IDs OMIM609855 MGI1918993 HomoloGene11889 GeneCards: COASY Gene
EC number 2.7.1.24, 2.7.7.3
RNA expression pattern
PBB GE COASY 201913 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 80347 71743
Ensembl ENSG00000068120 ENSMUSG00000001755
UniProt Q13057 Q9DBL7
RefSeq (mRNA) NM_001042529 NM_027896
RefSeq (protein) NP_001035994 NP_082172
Location (UCSC) Chr 17:
40.71 – 40.72 Mb
Chr 11:
101.08 – 101.09 Mb
PubMed search [1] [2]

Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[1][2][3]


Interactions[edit]

COASY has been shown to interact with P70-S6 Kinase 1.[4] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[5]

References[edit]

  1. ^ Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A (Jun 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". J Biol Chem 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312. 
  2. ^ Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (Jun 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". J Biol Chem 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892. 
  3. ^ "Entrez Gene: COASY Coenzyme A synthase". 
  4. ^ Nemazanyy, Ivan; Panasyuk Ganna; Zhyvoloup Alexander; Panayotou George; Gout Ivan T; Filonenko Valeriy (Dec 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. (Netherlands) 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. ISSN 0014-5793. PMID 15589845. 
  5. ^ Breus, Oksana; Panasyuk G; Gout IT; Filonenko V; Nemazanyy I (May 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway.". Biochem Biophys Res Commun. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007. 

Further reading[edit]