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Component of oligomeric golgi complex 7
Symbols COG7 ; CDG2E
External IDs OMIM606978 MGI2685013 HomoloGene33431 GeneCards: COG7 Gene
RNA expression pattern
PBB GE COG7 213190 at tn.png
More reference expression data
Species Human Mouse
Entrez 91949 233824
Ensembl ENSG00000168434 ENSMUSG00000034951
UniProt P83436 Q3UM29
RefSeq (mRNA) NM_153603 NM_001033318
RefSeq (protein) NP_705831 NP_001028490
Location (UCSC) Chr 16:
23.4 – 23.46 Mb
Chr 7:
121.92 – 121.98 Mb
PubMed search [1] [2]

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.[1][2]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM][2]


COG7 has been shown to interact with COG4[3] and COG5.[3]


  1. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916. 
  2. ^ a b "Entrez Gene: COG7 component of oligomeric golgi complex 7". 
  3. ^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 

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