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COI may refer to:
- California Oregon Intertie or Path 66, an electrical power transmission system
- Center on Organizational Innovation, a research center at Columbia University
- Central Office of Information, a former UK Government department
- Commission de l'Océan Indien or Indian Ocean Commission
- Community of inquiry, a concept describing the social quality of scientific inquiry
- Community of interest (computer security), a computer networking technique of segregation of resources
- Confirmed opt-in, a policy for obtaining mailing list recipients
- Conflict of interest
- Cytochrome Oxidase Subunit 1, a gene
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