Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1gene.
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
^Greenspan DS, Byers MG, Eddy RL, Cheng W, Jani-Sait S, Shows TB (May 1992). "Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome". Genomics12 (4): 836–7. doi:10.1016/0888-7543(92)90320-R. PMID1572660.
Greenspan DS, Cheng W, Hoffman GG (1992). "The pro-alpha 1(V) collagen chain. Complete primary structure, distribution of expression, and comparison with the pro-alpha 1(XI) collagen chain.". J. Biol. Chem.266 (36): 24727–33. PMID1722213.
Takahara K, Sato Y, Okazawa K, et al. (1991). "Complete primary structure of human collagen alpha 1 (V) chain.". J. Biol. Chem.266 (20): 13124–9. PMID2071595.
Seyer JM, Kang AH (1989). "Covalent structure of collagen: amino acid sequence of three cyanogen bromide-derived peptides from human alpha 1(V) collagen chain.". Arch. Biochem. Biophys.271 (1): 120–9. doi:10.1016/0003-9861(89)90262-2. PMID2496661.
Niyibizi C, Fietzek PP, van der Rest M (1984). "Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule.". J. Biol. Chem.259 (22): 14170–4. PMID6501291.
Takahara K, Hoffman GG, Greenspan DS (1996). "Complete structural organization of the human alpha 1 (V) collagen gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen genes.". Genomics29 (3): 588–97. doi:10.1006/geno.1995.9961. PMID8575750.
Tillet E, Ruggiero F, Nishiyama A, Stallcup WB (1997). "The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein.". J. Biol. Chem.272 (16): 10769–76. doi:10.1074/jbc.272.16.10769. PMID9099729.
Imamura Y, Scott IC, Greenspan DS (2000). "The pro-alpha3(V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains.". J. Biol. Chem.275 (12): 8749–59. doi:10.1074/jbc.275.12.8749. PMID10722718.