COMMD3-BMI1

COMMD3-BMI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H0D, 3RPG, 4R8P
Identifiers
Aliases	COMMD3-BMI1, COMMD3-BMI1 readthrough, BMI1, RNF51, PCGF4
External IDs	MGI: 88174 HomoloGene: 3797 GeneCards: COMMD3-BMI1
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.2 Start 22,316,388 bp End 22,329,542 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 12.9 cM Start 18,681,829 bp End 18,691,440 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum islet of Langerhans bone marrow cells sural nerve stromal cell of endometrium duodenum Achilles tendon thymus appendix ganglionic eminence Top expressed in secondary oocyte plantaris muscle extensor digitorum longus muscle superior surface of tongue medial ganglionic eminence interventricular septum gallbladder retinal pigment epithelium atrioventricular valve medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function promoter-specific chromatin binding RING-like zinc finger domain binding metal ion binding protein binding zinc ion binding Cellular component cytoplasm ubiquitin ligase complex nucleoplasm PRC1 complex PcG protein complex nucleus cytosol nuclear body Biological process regulation of transcription, DNA-templated positive regulation of fibroblast proliferation negative regulation of transcription by RNA polymerase II transcription, DNA-templated segment specification negative regulation of gene expression, epigenetic positive regulation of ubiquitin-protein transferase activity regulation of gene expression histone H2A-K119 monoubiquitination negative regulation of G0 to G1 transition chromatin organization hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100532731 12151 Ensembl ENSG00000269897 ENSMUSG00000026739 UniProt P35226 P25916 RefSeq (mRNA) NM_001204062 NM_007552 RefSeq (protein) NP_001190991 NP_005171 NP_031578 Location (UCSC) Chr 10: 22.32 – 22.33 Mb Chr 2: 18.68 – 18.69 Mb PubMed search
Wikidata
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The COMMD3-BMI1 gene in humans encodes the COMMD3-BMI1 readthrough protein.

Function

This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.