From Wikipedia, the free encyclopedia
Jump to: navigation, search
Coatomer protein complex, subunit beta 2 (beta prime)
Symbols COPB2 ; beta'-COP
External IDs OMIM606990 MGI1354962 HomoloGene3499 GeneCards: COPB2 Gene
RNA expression pattern
PBB GE COPB2 201098 at tn.png
More reference expression data
Species Human Mouse
Entrez 9276 50797
Ensembl ENSG00000184432 ENSMUSG00000032458
UniProt P35606 O55029
RefSeq (mRNA) NM_004766 NM_015827
RefSeq (protein) NP_004757 NP_056642
Location (UCSC) Chr 3:
139.07 – 139.11 Mb
Chr 9:
98.56 – 98.59 Mb
PubMed search [1] [2]

Coatomer subunit beta' is a protein that in humans is encoded by the COPB2 gene.[1][2]

The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM][2]


COPB2 has been shown to interact with RGS4,[3] PRKCE[4] and COPB1.[5][6]


  1. ^ De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (February 1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet 82 (3–4): 226–7. doi:10.1159/000015107. PMID 9858824. 
  2. ^ a b "Entrez Gene: COPB2 coatomer protein complex, subunit beta 2 (beta prime)". 
  3. ^ Sullivan, B M; Harrison-Lavoie K J; Marshansky V; Lin H Y; Kehrl J H; Ausiello D A; Brown D; Druey K M (September 2000). "RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport". Mol. Biol. Cell (UNITED STATES) 11 (9): 3155–68. doi:10.1091/mbc.11.9.3155. ISSN 1059-1524. PMC 14982. PMID 10982407. 
  4. ^ England, Karen; Ashford David; Kidd Daniel; Rumsby Martin (June 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. (England) 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. ISSN 0898-6568. PMID 11897493. 
  5. ^ Eugster, A; Frigerio G; Dale M; Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. (ENGLAND) 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. ISSN 0261-4189. PMC 306616. PMID 10921873. 
  6. ^ Lowe, M; Kreis T E (November 1996). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. (UNITED STATES) 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050. 

Further reading[edit]