COPE (gene)

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Coatomer protein complex, subunit epsilon
Symbols COPE ; epsilon-COP
External IDs OMIM606942 MGI1891702 HomoloGene5254 GeneCards: COPE Gene
RNA expression pattern
PBB GE COPE 201264 at tn.png
More reference expression data
Species Human Mouse
Entrez 11316 59042
Ensembl ENSG00000105669 ENSMUSG00000055681
UniProt O14579 O89079
RefSeq (mRNA) NM_007263 NM_021538
RefSeq (protein) NP_009194 NP_067513
Location (UCSC) Chr 19:
19.01 – 19.03 Mb
Chr 8:
70.3 – 70.31 Mb
PubMed search [1] [2]

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.[1][2]


The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


COPE (gene) has been shown to interact with COPA.[3][4][5]


  1. ^ Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821–4. doi:10.1016/S0960-9822(99)80365-0. PMID 10469566. 
  2. ^ a b "Entrez Gene: COPE coatomer protein complex, subunit epsilon". 
  3. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  4. ^ Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873. 
  5. ^ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F et al. (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162. 

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