COUP-TFII

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Nuclear receptor subfamily 2, group F, member 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NR2F2 ; ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
External IDs OMIM107773 MGI1352452 HomoloGene7628 IUPHAR: NR2F2 GeneCards: NR2F2 Gene
RNA expression pattern
PBB GE NR2F2 209120 at tn.png
PBB GE NR2F2 209121 x at tn.png
PBB GE NR2F2 215073 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7026 11819
Ensembl ENSG00000185551 ENSMUSG00000030551
UniProt P24468 P43135
RefSeq (mRNA) NM_001145155 NM_009697
RefSeq (protein) NP_001138627 NP_033827
Location (UCSC) Chr 15:
96.87 – 96.88 Mb
Chr 7:
70.35 – 70.37 Mb
PubMed search [1] [2]

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.[1][2] The COUP acronym stands for chicken ovalbumin upstream promoter.

Function[edit]

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.[3][4]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.[5][6] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.[7]

Interactions[edit]

COUP-TFII has been shown to interact with:

References[edit]

  1. ^ "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2". 
  2. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert D, Copeland N, Gibson L et al. (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078. 
  3. ^ Pereira F, Qiu Y, Zhou G, Tsai M, Tsai S (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. doi:10.1101/gad.13.8.1037. PMC 316637. PMID 10215630. 
  4. ^ Lee C, Li L, Takamoto N, Martin J, Demayo F, Tsai M et al. (December 2004). "The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development". Mol. Cell. Biol. 24 (24): 10835–43. doi:10.1128/MCB.24.24.10835-10843.2004. PMC 533959. PMID 15572686. 
  5. ^ De Martino M, Bhattachryya N, Alesci S, Ichijo T, Chrousos G, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. doi:10.1210/me.2003-0341. PMID 14739255. 
  6. ^ De Martino M, Alesci S, Chrousos G, Kino T (June 2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774. 
  7. ^ Xu Z, Yu S, Hsu C, Eguchi J, Rosen E (February 2008). "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. doi:10.1073/pnas.0707082105. PMC 2268152. PMID 18250317. 
  8. ^ Smirnov D, Hou S, Ricciardi R (March 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. doi:10.1006/viro.1999.0181. PMID 10704340. 
  9. ^ Marcus S, Winrow C, Capone J, Rachubinski R (November 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. doi:10.1074/jbc.271.44.27197. PMID 8910285. 
  10. ^ Avram D, Ishmael J, Nevrivy D, Peterson V, Lee S, Dowell P et al. (May 1999). "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855. 
  11. ^ Litchfield L, Riggs K, Hockenberry A, Oliver L, Barnhart K, Cai J et al. (May 2012). "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.". PLoS One 7 (5). doi:10.1371/journal.pone.0038278. PMC 3365040. PMID 22693611. 

Further reading[edit]