From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cytochrome c oxidase assembly homolog 15 (yeast)
Symbols COX15 ; CEMCOX2
External IDs OMIM603646 MGI1920112 HomoloGene5848 GeneCards: COX15 Gene
RNA expression pattern
PBB GE COX15 219547 at tn.png
PBB GE COX15 221550 at tn.png
More reference expression data
Species Human Mouse
Entrez 1355 226139
Ensembl ENSG00000014919 ENSMUSG00000040018
UniProt Q7KZN9 Q8BJ03
RefSeq (mRNA) NM_004376 NM_144874
RefSeq (protein) NP_004367 NP_659123
Location (UCSC) Chr 10:
101.47 – 101.49 Mb
Chr 19:
43.73 – 43.75 Mb
PubMed search [1] [2]

Cytochrome c oxidase assembly protein COX15 homolog is an enzyme that in humans is encoded by the COX15 gene.[1][2]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates several transcript variants diverging in the 3' region including alternate poly A sites. In total, 2 different isoforms are encoded by these variants.[2]


  1. ^ Petruzzella V, Tiranti V, Fernandez P, Ianna P, Carrozzo R, Zeviani M (Feb 1999). "Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain". Genomics 54 (3): 494–504. doi:10.1006/geno.1998.5580. PMID 9878253. 
  2. ^ a b "Entrez Gene: COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast)". 

Further reading[edit]