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Cytochrome c oxidase subunit Vb
Symbols COX5B ; COXVB
External IDs OMIM123866 MGI88475 HomoloGene37538 GeneCards: COX5B Gene
EC number
RNA expression pattern
PBB GE COX5B 213735 s at tn.png
PBB GE COX5B 202343 x at tn.png
PBB GE COX5B 211025 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1329 12859
Ensembl ENSG00000135940 ENSMUSG00000061518
UniProt P10606 P19536
RefSeq (mRNA) NM_001862 NM_009942
RefSeq (protein) NP_001853 NP_034072
Location (UCSC) Chr 2:
98.26 – 98.26 Mb
Chr 1:
36.69 – 36.69 Mb
PubMed search [1] [2]

Cytochrome c oxidase subunit 5B, mitochondrial is an enzyme that in humans is encoded by the COX5B gene.[1]

Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.[1]


COX5B has been shown to interact with Androgen receptor.[2]


  1. ^ a b "Entrez Gene: COX5B cytochrome c oxidase subunit Vb". 
  2. ^ Beauchemin, A M; Gottlieb B; Beitel L K; Elhaji Y A; Pinsky L; Trifiro M A (2001). "Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy". Brain Res. Bull. (United States) 56 (3–4): 285–97. doi:10.1016/S0361-9230(01)00583-4. ISSN 0361-9230. PMID 11719263. 

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