COX7A1
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| Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | COX7A1; COX7A; COX7AH; COX7AM | ||||||||||||
| External IDs | OMIM: 123995 MGI: 1316714 HomoloGene: 48051 GeneCards: COX7A1 Gene | ||||||||||||
| EC number | 1.9.3.1 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1346 | 12865 | |||||||||||
| Ensembl | ENSG00000161281 | ENSMUSG00000074218 | |||||||||||
| UniProt | P24310 | P56392 | |||||||||||
| RefSeq (mRNA) | NM_001864.2 | NM_009944.3 | |||||||||||
| RefSeq (protein) | NP_001855.1 | NP_034074.1 | |||||||||||
| Location (UCSC) | Chr 19: 36.64 – 36.64 Mb |
Chr 7: 30.97 – 30.97 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.[1][2][3]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.[3]
[edit] References
- ^ Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
- ^ Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA (Oct 1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res 17 (17): 7107–7107. doi:10.1093/nar/17.17.7107. PMC 318441. PMID 2550906. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=318441.
- ^ a b "Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1346.
[edit] Further reading
- Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol.. Progress in Nucleic Acid Research and Molecular Biology 61: 309–344. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
- Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–199. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID 1309697.
- Wolz W, Kress W, Mueller CR (1998). "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M". Genomics 45 (2): 438–442. doi:10.1006/geno.1997.4937. PMID 9344674.
- Schmidt TR, Goodman M, Grossman LI (1999). "Molecular evolution of the COX7A gene family in primates". Mol. Biol. Evol. 16 (5): 619–26. PMID 10335655.
- Yu M, Jaradat SA, Grossman LI (2002). "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)". Biochim. Biophys. Acta 1574 (3): 345–53. PMID 11997101.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Grimwood J, Gordon LA, Olsen A et al (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–535. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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