CP-154,526

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CP-154,526
CP154526.svg
Identifiers
CAS number 157286-86-7
PubChem 5311055
ChemSpider 4470592
ChEMBL CHEMBL9946
Jmol-3D images Image 1
Properties
Molecular formula C23H32N4
Molar mass 364.52698
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.[1]

CP-154,526 is under investigation for the potential treatment of alcoholism.[2][3]

See also[edit]

References[edit]

  1. ^ Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J (September 1996). "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10477–82. doi:10.1073/pnas.93.19.10477. PMC 38410. PMID 8816826. 
  2. ^ "Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2008-08-02. Retrieved 2008-08-09. 
  3. ^ Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). "Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: A urocortin1-independent mechanism". Proc. Natl. Acad. Sci. U.S.A. 105 (26): 9070–5. doi:10.1073/pnas.0710181105. PMC 2449366. PMID 18591672. 

External links[edit]