CP-93,129

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CP-93,129
CP-93129 structure.png
Systematic (IUPAC) name
3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one
Clinical data
Legal status ?
Identifiers
CAS number 127792-75-0
ATC code ?
PubChem CID 124007
ChemSpider 110524
Chemical data
Formula C12H13N3O 
Mol. mass 215.251 g/mol

CP-93,129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.[2][3][4][5]


References[edit]

  1. ^ Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK, et al. 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. Journal of Medicinal Chemistry. 1990 Aug;33(8):2087-93. PMID 2374139
  2. ^ De Groote L, Olivier B, Westenberg HG. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European Journal of Pharmacology. 2003 Aug 22;476(1-2):71-7. PMID 12969751
  3. ^ Przegaliński E, Papla I, Siwanowicz J, Filip M. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. European Neuropsychopharmacology. 2004 May;14(3):217-25. PMID 15056481
  4. ^ Bramley JR, Sollars PJ, Pickard GE, Dudek FE. 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus. Journal of Neurophysiology. 2005 Jun;93(6):3157-64. PMID 15716370
  5. ^ Saitow F, Murano M, Suzuki H. Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei. Journal of Neurophysiology. 2009 Mar;101(3):1361-74. PMID 19144744