CPD (gene)

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Carboxypeptidase D
Symbols CPD ; GP180
External IDs OMIM603102 MGI107265 HomoloGene999 GeneCards: CPD Gene
EC number
RNA expression pattern
PBB GE CPD 201941 at tn.png
PBB GE CPD 201940 at tn.png
PBB GE CPD 201942 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1362 12874
Ensembl ENSG00000108582 ENSMUSG00000020841
UniProt O75976 O89001
RefSeq (mRNA) NM_001199775 NM_007754
RefSeq (protein) NP_001186704 NP_031780
Location (UCSC) Chr 17:
28.71 – 28.8 Mb
Chr 11:
76.78 – 76.85 Mb
PubMed search [1] [2]

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.[1][2][3]

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities: the pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[3]


  1. ^ Riley DA, Tan F, Miletich DJ, Skidgel RA (Apr 1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828. 
  2. ^ Tan F, Rehli M, Krause SW, Skidgel RA (Dec 1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". Biochem J 327 (Pt 1): 81–7. PMC 1218766. PMID 9355738. 
  3. ^ a b "Entrez Gene: CPD carboxypeptidase D". 

Further reading[edit]