From Wikipedia, the free encyclopedia
Jump to: navigation, search
Copine IV
Symbols CPNE4 ; COPN4; CPN4
External IDs OMIM604208 MGI1921270 HomoloGene26078 GeneCards: CPNE4 Gene
RNA expression pattern
PBB GE CPNE4 gnf1h09017 at tn.png
More reference expression data
Species Human Mouse
Entrez 131034 74020
Ensembl ENSG00000196353 ENSMUSG00000032564
UniProt Q96A23 Q8BLR2
RefSeq (mRNA) NM_001289112 NM_028719
RefSeq (protein) NP_001276041 NP_082995
Location (UCSC) Chr 3:
131.25 – 132 Mb
Chr 9:
104.55 – 105.03 Mb
PubMed search [1] [2]

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.[1][2][3]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[3]


  1. ^ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674. 
  2. ^ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun 303 (3): 842–7. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487. 
  3. ^ a b "Entrez Gene: CPNE4 copine IV". 

Further reading[edit]