CPSF4

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Cleavage and polyadenylation specific factor 4, 30kDa
Protein CPSF4 PDB 2d9n.png
PDB rendering based on 2d9n.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CPSF4 ; CPSF30; NAR; NEB1
External IDs OMIM603052 MGI1861602 HomoloGene38216 GeneCards: CPSF4 Gene
RNA expression pattern
PBB GE CPSF4 206688 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10898 54188
Ensembl ENSG00000160917 ENSMUSG00000029625
UniProt O95639 Q8BQZ5
RefSeq (mRNA) NM_001081559 NM_178576
RefSeq (protein) NP_001075028 NP_848671
Location (UCSC) Chr 7:
99.04 – 99.05 Mb
Chr 5:
145.17 – 145.18 Mb
PubMed search [1] [2]

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.[1][2][3]

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.[3]

References[edit]

  1. ^ Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM (Jul 1998). "Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs". Mol Cell 1 (7): 991–1000. doi:10.1016/S1097-2765(00)80099-4. PMID 9651582. 
  2. ^ Barabino SM, Hubner W, Jenny A, Minvielle-Sebastia L, Keller W (Aug 1997). "The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins". Genes Dev 11 (13): 1703–16. doi:10.1101/gad.11.13.1703. PMID 9224719. 
  3. ^ a b "Entrez Gene: CPSF4 cleavage and polyadenylation specific factor 4, 30kDa". 

Further reading[edit]