CP 55,940
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| Systematic (IUPAC) name | |
|---|---|
| 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenol | |
| Identifiers | |
| CAS number | 83002-04-4 |
| ATC code | ? |
| PubChem | 3086156 |
| Chemical data | |
| Formula | C24H40O3 |
| Mol. mass | 376.573 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ?
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CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in marijuana). CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the endocannabinoid system. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice. CP 55,940 is 45 times more potent than Δ9-THC, and fully antagonized by rimonabant (SR141716A).[1] CP 55,940 is considered a full agonist at both CB1 and CB2 receptors and has ki values of 0.58nM and 0.68nM respectively. [2]
There is no information on the dangers or neurotoxicity of CP 55,940 except what can be inferred from its similarity to other cannabinoids, which typically exhibit neuroprotective properties.
CP 55,940 reportedly produces cannabis-like effects in humans, albeit with a significantly longer duration of effects, at doses as low as 0.25 - 1 milligrams and could potentially be used as an alternative to medicinal marijuana. Amongst recreational drug users, there is considerable concern about CP 55,940's instability, and the reported dosage required for notable effects varies from under 1 milligram to over 20. Some scientific suppliers (BIOMOL, Tocris) advise storing this compound at -20°C, but others (Sigma-Aldrich) recommend 2-8°C. As a cannabinoid, CP 55,940 is most likely labile to light and air exposure as well. If stored in a cool, dark, airtight location, notable degradation would likely require a minimum of several months.
[edit] References
- ^ Rinaldi-Carmona M, Pialot F, Congy C, Redon E, Barth F, Bachy A, Brelière JC, Soubrié P, Le Fur G. "Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain." Life Sci 1996, 58:1239-47. PMID 8614277
- ^ http://www.google.com/url?sa=t&source=web&ct=res&cd=5&url=http%3A%2F%2Fwww.caymanchem.com%2Fapp%2Fscreen%2FProductPrintable%2Fcatalog%2F90084%2Fa%2Fz%3Bjsessionid%3D33A33316D38894F0CAAA3A5420A27ABC&ei=1K8MSt77J5OMtgOJiM2JAw&rct=j&q=%22ki+values%22+cp-55%2C940&usg=AFQjCNE_BcVxoSRnykbO8ZT48WT6Ursnbg
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