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Cysteine-rich with EGF-like domains 1
External IDs OMIM607170 MGI2152539 HomoloGene32265 GeneCards: CRELD1 Gene
RNA expression pattern
PBB GE CRELD1 203368 at tn.png
More reference expression data
Species Human Mouse
Entrez 78987 171508
Ensembl ENSG00000163703 ENSMUSG00000030284
UniProt Q96HD1 Q91XD7
RefSeq (mRNA) NM_001031717 NM_133930
RefSeq (protein) NP_001026887 NP_598691
Location (UCSC) Chr 3:
9.98 – 9.99 Mb
Chr 6:
113.48 – 113.49 Mb
PubMed search [1] [2]

Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.[1][2][3]


Epidermal growth factor (EGF)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.[3]


  1. ^ Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER (Sep 2000). "Detailed mapping of a congenital heart disease gene in chromosome 3p25". J Med Genet 37 (8): 581–7. doi:10.1136/jmg.37.8.581. PMC 1734659. PMID 10922384. 
  2. ^ Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL (Jul 2002). "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins". Gene 293 (1–2): 47–57. doi:10.1016/S0378-1119(02)00696-0. PMID 12137942. 
  3. ^ a b "Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1". 

Further reading[edit]