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CREB regulated transcription coactivator 1
Symbols CRTC1 ; MECT1; TORC-1; TORC1; WAMTP1
External IDs OMIM607536 MGI2142523 HomoloGene41607 GeneCards: CRTC1 Gene
RNA expression pattern
PBB GE CRTC1 207159 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23373 382056
Ensembl ENSG00000105662 ENSMUSG00000003575
UniProt Q6UUV9 Q68ED7
RefSeq (mRNA) NM_001098482 NM_001004062
RefSeq (protein) NP_001091952 NP_001004062
Location (UCSC) Chr 19:
18.79 – 18.89 Mb
Chr 8:
70.38 – 70.44 Mb
PubMed search [1] [2]

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1, not to be confused with the unrelated target of rapamycin complex 1 (mTORC1)) is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands.[5]

Clinical significance[edit]

Production of CRTC1 is blocked in Alzheimer's disease.[6]

See also[edit]


  1. ^ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Jan 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nat Genet 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. 
  2. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Oct 2003). "TORCs: transducers of regulated CREB activity". Mol Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  3. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc Natl Acad Sci U S A 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290. 
  4. ^ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1". 
  5. ^ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers. 
  6. ^ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". J. Neurosci. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.