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CREB regulated transcription coactivator 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CRTC2 ; TORC-2; TORC2
External IDs OMIM608972 MGI1921593 HomoloGene18765 GeneCards: CRTC2 Gene
Species Human Mouse
Entrez 200186 74343
Ensembl ENSG00000160741 ENSMUSG00000027936
UniProt Q53ET0 Q3U182
RefSeq (mRNA) NM_181715 NM_028881
RefSeq (protein) NP_859066 NP_083157
Location (UCSC) Chr 1:
153.92 – 153.93 Mb
Chr 3:
90.25 – 90.26 Mb
PubMed search [1] [2]

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[1][2][3]


CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[4]


CRTC2 has been shown to interact with SNF1LK2[5] and YWHAQ.[5][6]


  1. ^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2". 
  2. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290. 
  3. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  4. ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". Bioessays 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585. 
  5. ^ a b Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell (United States) 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. ISSN 0092-8674. PMID 15454081. 
  6. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

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