CRTC3

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CREB regulated transcription coactivator 3
Identifiers
Symbols CRTC3 ; TORC-3; TORC3
External IDs OMIM608986 MGI1917711 HomoloGene11248 GeneCards: CRTC3 Gene
Orthologs
Species Human Mouse
Entrez 64784 70461
Ensembl ENSG00000140577 ENSMUSG00000030527
UniProt Q6UUV7 Q91X84
RefSeq (mRNA) NM_001042574 NM_173863
RefSeq (protein) NP_001036039 NP_776288
Location (UCSC) Chr 15:
91.07 – 91.19 Mb
Chr 7:
80.59 – 80.69 Mb
PubMed search [1] [2]

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[1][2][3]

This gene has been shown to be linked to weight gain.[4]


References[edit]

  1. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Oct 2003). "TORCs: transducers of regulated CREB activity". Mol Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  2. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc Natl Acad Sci U S A 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290. 
  3. ^ "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3". 
  4. ^ Song, Youngsup; Altarejos, Judith; Goodarzi, Mark O.; Inoue, Hiroshi; Guo, Xiuqing; Berdeaux, Rebecca; Kim, Jeong-Ho; Goode, Jason; Igata, Motoyuki; Paz, Jose C.; Hogan, Meghan F.; Singh, Pankaj K.; Goebel, Naomi; Vera, Lili; Miller, Nina; Cui, Jinrui; Jones, Michelle R.; Consortium, CHARGE; Consortium, GIANT; Chen, Yii-Der I.; Taylor, Kent D.; Hsueh, Willa A.; Rotter, Jerome I.; Montminy, Marc (16 December 2010). "CRTC3 links catecholamine signalling to energy balance". Nature 468 (7326): 933–939. doi:10.1038/nature09564. 

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