Granulocyte macrophage colony-stimulating factor receptor

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Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CSF2RA ; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; SMDP4
External IDs OMIM425000 MGI1339754 HomoloGene48406 ChEMBL: 2020 GeneCards: CSF2RA Gene
RNA expression pattern
PBB GE CSF2RA 210340 s at tn.png
PBB GE CSF2RA 207085 x at tn.png
PBB GE CSF2RA 211286 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1438 12982
Ensembl ENSG00000198223 ENSMUSG00000059326
UniProt P15509 Q00941
RefSeq (mRNA) NM_001161529 NM_009970
RefSeq (protein) NP_001155001 NP_034100
Location (UCSC) Chr X:
1.39 – 1.43 Mb
Chr 19:
61.22 – 61.23 Mb
PubMed search [1] [2]

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[1]

It is associated with Surfactant metabolism dysfunction type 4.

Structure[edit]

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[3]

Signal transduction[edit]

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.[4]

References[edit]

  1. ^ Nicola NA, Metcalf D (1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". J. Cell. Physiol. 124 (2): 313–321. doi:10.1002/jcp.1041240222. PMID 3876343. 
  2. ^ McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF (2003). "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex". Blood 101 (4): 1308–1315. doi:10.1182/blood-2002-06-1903. PMID 12393492. 
  3. ^ a b Geijsen N, Koenderman L, Coffer PJ (2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine Growth Factor Rev. 12 (1): 19–25. doi:10.1016/S1359-6101(00)00019-8. PMID 11312115. 
  4. ^ Doyle SE, Gasson JC (1998). "Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5" (– Scholar search). Blood 92 (3): 867–76. PMID 9680354. [dead link]

Further reading[edit]

External links[edit]