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Chondroitin sulfate proteoglycan 4
External IDs OMIM601172 MGI2153093 HomoloGene20445 GeneCards: CSPG4 Gene
RNA expression pattern
PBB GE CSPG4 204736 s at tn.png
PBB GE CSPG4 214297 at tn.png
More reference expression data
Species Human Mouse
Entrez 1464 121021
Ensembl ENSG00000173546 ENSMUSG00000032911
UniProt Q6UVK1 Q8VHY0
RefSeq (mRNA) NM_001897 NM_139001
RefSeq (protein) NP_001888 NP_620570
Location (UCSC) Chr 15:
75.97 – 76.01 Mb
Chr 9:
56.87 – 56.9 Mb
PubMed search [1] [2]

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2),[1] is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[2][3][4]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[4]

See also[edit]


  1. ^ Birbrair, Alexander; Zhang, Tan; Wang, Zhong-Min; Messi, Maria Laura; Enikolopov, Grigori N.; Mintz, Akiva; Delbono, Osvaldo (2013). "Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation". Stem Cells and Development 22 (16): 2298–314. doi:10.1089/scd.2012.0647. PMC 3730538. PMID 23517218. 
  2. ^ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494. PMID 8790396. 
  3. ^ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841. 
  4. ^ a b "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4". 

Further reading[edit]