CST2

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Cystatin SA
Identifiers
Symbols CST2 ; MGC71924
External IDs OMIM123856 HomoloGene55573 GeneCards: CST2 Gene
RNA expression pattern
PBB GE CST2 208555 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1470 n/a
Ensembl ENSG00000170369 n/a
UniProt P09228 n/a
RefSeq (mRNA) NM_001322 n/a
RefSeq (protein) NP_001313 n/a
Location (UCSC) Chr 20:
23.8 – 23.81 Mb
n/a
PubMed search [1] n/a

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.[1]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.[1]

References[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I25.009

Further reading[edit]