CST8 (gene)

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Cystatin 8 (cystatin-related epididymal specific)
Symbols CST8 ; CRES; CTES5
External IDs OMIM608683 MGI107161 HomoloGene4011 GeneCards: CST8 Gene
RNA expression pattern
PBB GE CST8 220627 at tn.png
More reference expression data
Species Human Mouse
Entrez 10047 13012
Ensembl ENSG00000125815 ENSMUSG00000027442
UniProt O60676 P32766
RefSeq (mRNA) NM_005492 NM_009978
RefSeq (protein) NP_005483 NP_034108
Location (UCSC) Chr 20:
23.47 – 23.48 Mb
Chr 2:
148.8 – 148.81 Mb
PubMed search [1] [2]

Cystatin-8 is a protein that in humans is encoded by the CST8 gene.[1][2]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined.[2]


  1. ^ Cornwall GA, Hann SR (Aug 1995). "Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation". Mol Reprod Dev 41 (1): 37–46. doi:10.1002/mrd.1080410107. PMID 7619504. 
  2. ^ a b "Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)". 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I25.027

Further reading[edit]

External links[edit]