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Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
Protein CSTF2 PDB 1p1t.png
PDB rendering based on 1p1t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CSTF2 ; CstF-64
External IDs OMIM300907 MGI1343054 HomoloGene80171 GeneCards: CSTF2 Gene
RNA expression pattern
PBB GE CSTF2 204459 at tn.png
More reference expression data
Species Human Mouse
Entrez 1478 108062
Ensembl ENSG00000101811 ENSMUSG00000031256
UniProt P33240 Q8BIQ5
RefSeq (mRNA) NM_001325 NM_001290398
RefSeq (protein) NP_001316 NP_001277327
Location (UCSC) Chr X:
100.08 – 100.1 Mb
Chr X:
134.06 – 134.09 Mb
PubMed search [1] [2]

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[1][2]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[2]


CSTF2 has been shown to interact with CSTF3,[3] SUB1,[4] SYMPK,[3] BARD1[5][6] and BRCA1.[5][6]


  1. ^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A 89 (4): 1403–7. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396. 
  2. ^ a b "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa". 
  3. ^ a b Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. (UNITED STATES) 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729. 
  4. ^ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell (United States) 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848. 
  5. ^ a b Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell (United States) 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228. 
  6. ^ a b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science (UNITED STATES) 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523. 

Further reading[edit]