CSTF2

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Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
Protein CSTF2 PDB 1p1t.png
PDB rendering based on 1p1t.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CSTF2 ; CstF-64
External IDs OMIM300907 MGI1343054 HomoloGene80171 GeneCards: CSTF2 Gene
RNA expression pattern
PBB GE CSTF2 204459 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1478 108062
Ensembl ENSG00000101811 ENSMUSG00000031256
UniProt P33240 Q8BIQ5
RefSeq (mRNA) NM_001325 NM_001290398
RefSeq (protein) NP_001316 NP_001277327
Location (UCSC) Chr X:
100.08 – 100.1 Mb
Chr X:
134.06 – 134.09 Mb
PubMed search [1] [2]

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[1][2]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[2]

Interactions[edit]

CSTF2 has been shown to interact with CSTF3,[3] SUB1,[4] SYMPK,[3] BARD1[5][6] and BRCA1.[5][6]

References[edit]

  1. ^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A 89 (4): 1403–7. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396. 
  2. ^ a b "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa". 
  3. ^ a b Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. (UNITED STATES) 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729. 
  4. ^ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell (United States) 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848. 
  5. ^ a b Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell (United States) 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228. 
  6. ^ a b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science (UNITED STATES) 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523. 

Further reading[edit]