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This article is about an enzyme. For Comprehensive Tests of Basic Skills, see CTB/McGraw-Hill.
Chitobiase, di-N-acetyl-
Symbols CTBS ; CTB
External IDs OMIM600873 MGI1921495 HomoloGene3231 GeneCards: CTBS Gene
EC number 3.2.1.-
RNA expression pattern
PBB GE CTBS 218923 at tn.png
PBB GE CTBS 218924 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1486 74245
Ensembl ENSG00000117151 ENSMUSG00000028189
UniProt Q01459 Q8R242
RefSeq (mRNA) NM_004388 NM_001293672
RefSeq (protein) NP_004379 NP_001280601
Location (UCSC) Chr 1:
85.02 – 85.04 Mb
Chr 3:
146.45 – 146.47 Mb
PubMed search [1] [2]

Di-N-acetylchitobiase is an enzyme that in humans is encoded by the CTBS gene.[1][2][3]


  1. ^ Fisher KJ, Aronson NN Jr (Apr 1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol Cell Biol 12 (4): 1585–91. PMC 369601. PMID 1549114. 
  2. ^ Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925. 
  3. ^ "Entrez Gene: CTBS chitobiase, di-N-acetyl-". 

Further reading[edit]

  • Aronson NN, Halloran BA (2006). "Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase.". Biosci. Biotechnol. Biochem. 70 (6): 1537–41. doi:10.1271/bbb.60183. PMID 16794344. 
  • Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Hutchinson T, Dwivedi K, Rastogi A, et al. (2002). "N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor.". Asian J. Androl. 4 (1): 27–33. PMID 11907625. 
  • Liu B, Ahmad W, Aronson NN (1999). "Structure of the human gene for lysosomal di-N-acetylchitobiase.". Glycobiology 9 (6): 589–93. doi:10.1093/glycob/9.6.589. PMID 10336991. 
  • Aronson NN, Backes M, Kuranda MJ (1989). "Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins.". Arch. Biochem. Biophys. 272 (2): 290–300. doi:10.1016/0003-9861(89)90222-1. PMID 2751306. 
  • Fisher KJ, Aronson NN (1992). "Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase.". J. Biol. Chem. 267 (27): 19607–16. PMID 1527079.