CTCFL

CCCTC-binding factor (zinc finger protein)-like
Identifiers
Symbols	CTCFL; BORIS; CT27; CTCF-T; HMGB1L1; dJ579F20.2
External IDs	OMIM: 607022 MGI: 3652571 HomoloGene: 46476 GeneCards: CTCFL Gene
Gene Ontology Molecular function • DNA binding • protein binding • zinc ion binding • histone binding • sequence-specific DNA binding • transcription regulatory region DNA binding • metal ion binding Cellular component • intracellular • nucleus • nucleus • cytoplasm Biological process • regulation of gene expression by genetic imprinting • cell cycle • positive regulation of gene expression • chromatin modification • histone methylation • DNA methylation involved in gamete generation • positive regulation of transcription, DNA-dependent • regulation of histone H3-K4 methylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140690	664799
Ensembl	ENSG00000124092	ENSMUSG00000070495
UniProt	Q8NI51	A2APF3
RefSeq (mRNA)	NM_080618.2	NM_001081387.2
RefSeq (protein)	NP_542185.2	NP_001074856.1
Location (UCSC)	Chr 20: 56.07 – 56.1 Mb	Chr 2: 172.92 – 172.95 Mb
PubMed search	[1]	[2]

Transcriptional repressor CTCFL also known as BORIS (Brother of Regulator of Imprinted Sites) is a protein that in humans is encoded by the CTCFL gene.

Function

CCCTC-binding factor (CTCF), an 11-zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.

Further reading

• Klenova EM, Morse HC, Ohlsson R, Lobanenkov VV (2003). "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer.". Semin. Cancer Biol. 12 (5): 399–414. doi:10.1016/S1044-579X(02)00060-3. PMID 12191639. 
• D'Arcy V, Pore N, Docquier F, et al. (2008). "BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours.". Br. J. Cancer 98 (3): 571–9. doi:10.1038/sj.bjc.6604181. PMC 2243163. PMID 18195709. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2243163. 
• Woloszynska-Read A, James SR, Link PA, et al. (2008). "DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer.". Cancer Immun. 7: 21. PMC 2935752. PMID 18095639. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2935752. 
• Renaud S, Pugacheva EM, Delgado MD, et al. (2008). "Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors.". Nucleic Acids Res. 35 (21): 7372–88. doi:10.1093/nar/gkm896. PMC 2175345. PMID 17962299. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175345. 
• Kholmanskikh O, Loriot A, Brasseur F, et al. (2008). "Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.". Int. J. Cancer 122 (4): 777–84. doi:10.1002/ijc.23140. PMID 17957795. 
• Risinger JI, Chandramouli GV, Maxwell GL, et al. (2007). "Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.". Clin. Cancer Res. 13 (6): 1713–9. doi:10.1158/1078-0432.CCR-05-2569. PMID 17363524. 
• D'Arcy V, Abdullaev ZK, Pore N, et al. (2006). "The potential of BORIS detected in the leukocytes of breast cancer patients as an early marker of tumorigenesis.". Clin. Cancer Res. 12 (20 Pt 1): 5978–86. doi:10.1158/1078-0432.CCR-05-2731. PMID 17062669. 
• Hoffmann MJ, Müller M, Engers R, Schulz WA (2007). "Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies.". Biochem. Pharmacol. 72 (11): 1577–88. doi:10.1016/j.bcp.2006.06.020. PMID 16854382. 
• Hong JA, Kang Y, Abdullaev Z, et al. (2005). "Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.". Cancer Res. 65 (17): 7763–74. doi:10.1158/0008-5472.CAN-05-0823. PMID 16140944. 
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Loukinov DI, Pugacheva E, Vatolin S, et al. (2002). "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6806–11. doi:10.1073/pnas.092123699. PMC 124484. PMID 12011441. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124484. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 

External links

• FactorBook CTCFL