From Wikipedia, the free encyclopedia
Jump to: navigation, search
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Protein CTDP1 PDB 1onv.png
PDB rendering based on 1onv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CTDP1 ; CCFDN; FCP1
External IDs OMIM604927 MGI1926953 HomoloGene31254 GeneCards: CTDP1 Gene
EC number
RNA expression pattern
PBB GE CTDP1 205035 at tn.png
More reference expression data
Species Human Mouse
Entrez 9150 67655
Ensembl ENSG00000060069 ENSMUSG00000033323
UniProt Q9Y5B0 Q7TSG2
RefSeq (mRNA) NM_001202504 NM_026295
RefSeq (protein) NP_001189433 NP_080571
Location (UCSC) Chr 18:
77.44 – 77.51 Mb
Chr 18:
80.41 – 80.47 Mb
PubMed search [1] [2]

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[1][2][3]

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[3]


CTDP1 has been shown to interact with WD repeat-containing protein 77,[4] GTF2F1[2] and POLR2A.[5]


  1. ^ Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A 94 (26): 14300–5. doi:10.1073/pnas.94.26.14300. PMC 24951. PMID 9405607. 
  2. ^ a b Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293. 
  3. ^ a b "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1". 
  4. ^ Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. (England) 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496. 
  5. ^ Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119. 

Further reading[edit]