Cathepsin E

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Cathepsin E
Protein CTSE PDB 1tzs.png
PDB rendering based on 1tzs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CTSE ; CATE
External IDs OMIM116890 MGI107361 HomoloGene37551 ChEMBL: 3092 GeneCards: CTSE Gene
EC number 3.4.23.34
RNA expression pattern
PBB GE CTSE 205927 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1510 13034
Ensembl ENSG00000196188 ENSMUSG00000004552
UniProt P14091 P70269
RefSeq (mRNA) NM_001910 NM_007799
RefSeq (protein) NP_001901 NP_031825
Location (UCSC) Chr 1:
206.32 – 206.33 Mb
Chr 1:
131.64 – 131.68 Mb
PubMed search [1] [2]

Cathepsin E is a protein that in humans is encoded by the CTSE gene.[1][2][3]

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase A1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.[3]

References[edit]

  1. ^ Couvreur JM, Azuma T, Miller DA, Rocchi M, Mohandas TK, Boudi FA, Taggart RT (Aug 1990). "Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids". Cytogenet Cell Genet 53 (2-3): 137–9. doi:10.1159/000132914. PMID 2369841. 
  2. ^ Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT (Oct 1989). "Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases". J Biol Chem 264 (28): 16748–53. PMID 2674141. 
  3. ^ a b "Entrez Gene: CTSE cathepsin E". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: A01.010