Cathepsin F

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Cathepsin F
Protein CTSF PDB 1m6d.png
PDB rendering based on 1m6d.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CTSF ; CATSF; CLN13
External IDs OMIM603539 MGI1861434 HomoloGene31194 ChEMBL: 2517 GeneCards: CTSF Gene
EC number 3.4.22.41
RNA expression pattern
PBB GE CTSF 203657 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8722 56464
Ensembl ENSG00000174080 ENSMUSG00000083282
UniProt Q9UBX1 Q9R013
RefSeq (mRNA) NM_003793 NM_019861
RefSeq (protein) NP_003784 NP_063914
Location (UCSC) Chr 11:
66.33 – 66.34 Mb
Chr 19:
4.86 – 4.86 Mb
PubMed search [1] [2]

Cathepsin F is a protein that in humans is encoded by the CTSF gene.[1][2][3]

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. In general, cathepsins contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251-amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids that contains a 19-residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.[3]

References[edit]

  1. ^ Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D (Dec 1998). "Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization". J Biol Chem 273 (48): 32000–8. doi:10.1074/jbc.273.48.32000. PMID 9822672. 
  2. ^ Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C (Jun 1999). "Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain". J Biol Chem 274 (20): 13800–9. doi:10.1074/jbc.274.20.13800. PMID 10318784. 
  3. ^ a b "Entrez Gene: CTSF cathepsin F". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.018