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Cortactin binding protein 2
Symbols CTTNBP2 ; C7orf8; CORTBP2; Orf4
External IDs OMIM609772 MGI1353467 HomoloGene14125 GeneCards: CTTNBP2 Gene
RNA expression pattern
PBB GE CTTNBP2 gnf1h06054 at tn.png
More reference expression data
Species Human Mouse
Entrez 83992 30785
Ensembl ENSG00000077063 ENSMUSG00000000416
UniProt Q8WZ74 B9EJA2
RefSeq (mRNA) NM_033427 NM_080285
RefSeq (protein) NP_219499 NP_525024
Location (UCSC) Chr 7:
117.35 – 117.51 Mb
Chr 6:
18.37 – 18.51 Mb
PubMed search [1] [2]

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.[1][2]


This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[2]


CTTNBP2 has been shown to interact with:


  1. ^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics 78 (1-2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066. 
  2. ^ a b "Entrez Gene: CTTNBP2 cortactin binding protein 2". 
  3. ^ a b c d e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A et al. (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. 

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