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Cullin 2
Symbols CUL2 ; MGC131970
External IDs OMIM603135 MGI1918995 HomoloGene2662 GeneCards: CUL2 Gene
RNA expression pattern
PBB GE CUL2 203078 at tn.png
PBB GE CUL2 203079 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8453 71745
Ensembl ENSG00000108094 ENSMUSG00000024231
UniProt Q13617 Q9D4H8
RefSeq (mRNA) NM_001198777 NM_029402
RefSeq (protein) NP_001185706 NP_083678
Location (UCSC) Chr 10:
35.3 – 35.38 Mb
Chr 18:
3.38 – 3.44 Mb
PubMed search [1] [2]

Cullin-2 is a protein that in humans is encoded by the CUL2 gene.[1][2]


CUL2 has been shown to interact with DCUN1D1,[3] SAP130,[4] CAND1,[4][5] RBX1,[6][7] TCEB2[4][8] and Von Hippel-Lindau tumor suppressor.[4][8][9][10][11]


  1. ^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. 
  2. ^ "Entrez Gene: CUL2 cullin 2". 
  3. ^ Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. (United States) 283 (48): 33211–20. doi:10.1074/jbc.M804440200. ISSN 0021-9258. PMC 2586271. PMID 18826954. 
  4. ^ a b c d Menon, Suchithra; Tsuge Tomohiko; Dohmae Naoshi; Takio Koji; Wei Ning (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. (England) 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839. 
  5. ^ Min, Kyoeng-Woo; Hwang Ji-Won; Lee Jong-Sik; Park Yoon; Tamura Taka-aki; Yoon Jong-Bok (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. (United States) 278 (18): 15905–10. doi:10.1074/jbc.M213070200. ISSN 0021-9258. PMID 12609982. 
  6. ^ Dias, Dora C; Dolios Georgia; Wang Rong; Pan Zhen-Qiang (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (26): 16601–6. doi:10.1073/pnas.252646399. ISSN 0027-8424. PMC 139190. PMID 12481031. 
  7. ^ Ohta, T; Michel J J; Schottelius A J; Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell (UNITED STATES) 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407. 
  8. ^ a b Kamura, T; Burian D; Yan Q; Schmidt S L; Lane W S; Querido E; Branton P E; Shilatifard A; Conaway R C; Conaway J W (Aug 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. (United States) 276 (32): 29748–53. doi:10.1074/jbc.M103093200. ISSN 0021-9258. PMID 11384984. 
  9. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  10. ^ Ohh, M; Takagi Y; Aso T; Stebbins C E; Pavletich N P; Zbar B; Conaway R C; Conaway J W; Kaelin W G (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. (UNITED STATES) 104 (11): 1583–91. doi:10.1172/JCI8161. ISSN 0021-9738. PMC 481054. PMID 10587522. 
  11. ^ Hacker, Kathryn E; Lee Caroline Martz; Rathmell W Kimryn (2008). Zhang, Baohong, ed. "VHL type 2B mutations retain VBC complex form and function". PLoS ONE (United States) 3 (11): e3801. doi:10.1371/journal.pone.0003801. PMC 2583047. PMID 19030229. 

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