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Cullin 3
Protein CUL3 PDB 1iuy.png
PDB rendering based on 1iuy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CUL3 ; CUL-3; PHA2E
External IDs OMIM603136 MGI1347360 HomoloGene2661 GeneCards: CUL3 Gene
RNA expression pattern
PBB GE CUL3 201371 s at tn.png
PBB GE CUL3 201370 s at tn.png
PBB GE CUL3 201372 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8452 26554
Ensembl ENSG00000036257 ENSMUSG00000004364
UniProt Q13618 Q9JLV5
RefSeq (mRNA) NM_001257197 NM_016716
RefSeq (protein) NP_001244126 NP_057925
Location (UCSC) Chr 2:
225.33 – 225.45 Mb
Chr 1:
80.26 – 80.34 Mb
PubMed search [1] [2]

Cullin-3 is a protein that in humans is encoded by the CUL3 gene.[1][2][3]


CUL3 has been shown to interact with KLHL12,[4] CAND1,[5] KEAP1,[6][7] DCUN1D1[8] and Cyclin E1.[9]


  1. ^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. 
  2. ^ Wimuttisuk W, Singer JD (Feb 2007). "The Cullin3 Ubiquitin Ligase Functions as a Nedd8-bound Heterodimer". Mol Biol Cell 18 (3): 899–909. doi:10.1091/mbc.E06-06-0542. PMC 1805106. PMID 17192413. 
  3. ^ "Entrez Gene: CUL3 cullin 3". 
  4. ^ Rondou, Pieter; Haegeman Guy; Vanhoenacker Peter; Van Craenenbroeck Kathleen (Apr 2008). "BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase". J. Biol. Chem. (United States) 283 (17): 11083–96. doi:10.1074/jbc.M708473200. ISSN 0021-9258. PMC 2431063. PMID 18303015. 
  5. ^ Min, Kyoeng-Woo; Hwang Ji-Won; Lee Jong-Sik; Park Yoon; Tamura Taka-aki; Yoon Jong-Bok (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. (United States) 278 (18): 15905–10. doi:10.1074/jbc.M213070200. ISSN 0021-9258. PMID 12609982. 
  6. ^ Wang, Xiao-Jun; Sun Zheng; Chen Weimin; Li Yanjie; Villeneuve Nicole F; Zhang Donna D (Aug 2008). "Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction". Toxicol. Appl. Pharmacol. (United States) 230 (3): 383–9. doi:10.1016/j.taap.2008.03.003. ISSN 0041-008X. PMC 2610481. PMID 18417180. 
  7. ^ Rachakonda, Girish; Xiong Ying; Sekhar Konjeti R; Stamer Sheryl L; Liebler Daniel C; Freeman Michael L (Mar 2008). "Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3". Chem. Res. Toxicol. (United States) 21 (3): 705–10. doi:10.1021/tx700302s. ISSN 0893-228X. PMID 18251510. 
  8. ^ Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov 2008). "SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation". J. Biol. Chem. (United States) 283 (48): 33211–20. doi:10.1074/jbc.M804440200. ISSN 0021-9258. PMC 2586271. PMID 18826954. 
  9. ^ Singer, J D; Gurian-West M; Clurman B; Roberts J M (Sep 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. (UNITED STATES) 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. ISSN 0890-9369. PMC 317026. PMID 10500095. 

Further reading[edit]