Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2.[1][2] The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.[3]
[edit] References
- ^ Smith DF, Galkina E, Ley K, Huo Y (2005). "GRO family chemokines are specialized for monocyte arrest from flow". American journal of physiology. Heart and circulatory physiology 289 (5): H1976–84. doi:10.1152/ajpheart.00153.2005. PMID 15937099.
- ^ Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". The Journal of biological chemistry 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and cell genetics 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098.
|
|
|
| By family |
|
|
|
|
|
|
|
|
|
|
Type I
(grouped by
receptor
subunit)
|
|
|
|
|
|
|
|
|
|
|
|
|
IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNK, IFNW1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other
|
|
|
|
By function/
cell |
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
