CXCL7

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Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Protein PPBP PDB 1f9p.png
PDB rendering based on 1f9p.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PPBP ; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
External IDs OMIM121010 MGI1888712 HomoloGene48122 GeneCards: PPBP Gene
RNA expression pattern
PBB GE PPBP 214146 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5473 57349
Ensembl ENSG00000163736 ENSMUSG00000029372
UniProt P02775 Q9EQI5
RefSeq (mRNA) NM_002704 NM_023785
RefSeq (protein) NP_002695 NP_076274
Location (UCSC) Chr 4:
74.85 – 74.85 Mb
Chr 5:
90.77 – 90.77 Mb
PubMed search [1] [2]

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.[1]

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[2]

It is a protein that is released in large amounts from platelets following their activation.[3] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.[4][5]

References[edit]

  1. ^ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)". 
  2. ^ Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812. 
  3. ^ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem 266 (9): 5785–9. PMID 1826003. 
  4. ^ Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368. 
  5. ^ Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226. 

Further reading[edit]