CXCR5

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Chemokine (C-X-C motif) receptor 5
Identifiers
Symbols CXCR5 ; BLR1; CD185; MDR15
External IDs OMIM601613 MGI103567 HomoloGene1298 IUPHAR: CXCR5 ChEMBL: 1075315 GeneCards: CXCR5 Gene
RNA expression pattern
PBB GE BLR1 206126 at tn.png
PBB GE BLR1 216734 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 643 12145
Ensembl ENSG00000160683 ENSMUSG00000047880
UniProt P32302 Q04683
RefSeq (mRNA) NM_001716 NM_007551
RefSeq (protein) NP_001707 NP_031577
Location (UCSC) Chr 11:
118.75 – 118.77 Mb
Chr 9:
44.51 – 44.56 Mb
PubMed search [1] [2]

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.[1]

Tissue distribution and function[edit]

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.[2]

Clinical significance[edit]

CD4+CXCR5+ expression in T cells protects against mycobacterium tuberculosis (Mtb) infection.[3]

References[edit]

  1. ^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". Eur. J. Immunol. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907. 
  2. ^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell 87 (6): 1037–47. doi:10.1016/S0092-8674(00)81798-5. PMID 8978608. 
  3. ^ Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA (January 2013). "CXCR5+ T helper cells mediate protective immunity against tuberculosis". J. Clin. Invest. doi:10.1172/JCI65728. PMC 3561804. PMID 23281399. 


Further reading[edit]