CXCR5

Chemokine (C-X-C motif) receptor 5
Identifiers
Symbols	CXCR5; BLR1; CD185; MDR15; MGC117347
External IDs	OMIM: 601613 MGI: 103567 HomoloGene: 1298 IUPHAR: CXCR5 GeneCards: CXCR5 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • C-X-C chemokine receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • cellular component movement • G-protein coupled receptor protein signaling pathway • B cell activation • lymph node development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	643	12145
Ensembl	ENSG00000160683	ENSMUSG00000047880
UniProt	P32302	Q3V0L2
RefSeq (mRNA)	NM_001716.3	NM_007551.2
RefSeq (protein)	NP_001707.1	NP_031577.2
Location (UCSC)	Chr 11: 118.75 – 118.77 Mb	Chr 9: 44.32 – 44.33 Mb
PubMed search	[1]	[2]

C-X-C chemokine receptor type 5 (CXCR5) also known as Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.

CXCR5 has also recently been designated CD185 (cluster of differentiation 185).

External links

• "Chemokine Receptors: CXCR5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2218. 

Further reading

• Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.". Verhandlungen der Deutschen Gesellschaft für Pathologie 87: 90–101. PMID 16888899. 
• Dobner T, Wolf I, Emrich T, Lipp M (1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma.". Eur. J. Immunol. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907. 
• Barella L, Loetscher M, Tobler A, et al. (1995). "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.". Biochem. J. 309 (3): 773–9. PMC 1135699. PMID 7639692. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1135699. 
• Legler DF, Loetscher M, Roos RS, et al. (1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212150. 
• Gunn MD, Ngo VN, Ansel KM, et al. (1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.". Nature 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. 
• Müller G, Lipp M (2002). "Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules.". Biol. Chem. 382 (9): 1387–97. doi:10.1515/BC.2001.171. PMID 11688722. 
• Schaerli P, Loetscher P, Moser B (2002). "Cutting edge: induction of follicular homing precedes effector Th cell development.". J. Immunol. 167 (11): 6082–6. PMID 11714765. 
• Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.". Blood 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001. 
• Carlsen HS, Baekkevold ES, Johansen FE, et al. (2002). "B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.". Gut 51 (3): 364–71. doi:10.1136/gut.51.3.364. PMC 1773345. PMID 12171958. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1773345. 
• Battle TE, Yen A (2002). "Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.". Exp. Biol. Med. (Maywood) 227 (9): 753–62. PMID 12324654. 
• Lisignoli G, Toneguzzi S, Piacentini A, et al. (2003). "Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release.". J. Cell. Physiol. 194 (1): 71–9. doi:10.1002/jcp.10188. PMID 12447991. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chan CC, Shen D, Hackett JJ, et al. (2003). "Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma.". Ophthalmology 110 (2): 421–6. doi:10.1016/S0161-6420(02)01737-2. PMID 12578791. 
• Flynn G, Maru S, Loughlin J, et al. (2003). "Regulation of chemokine receptor expression in human microglia and astrocytes.". J. Neuroimmunol. 136 (1-2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646. 
• Lisignoli G, Piacentini A, Toneguzzi S, et al. (2004). "Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts.". Biogerontology 4 (5): 309–17. doi:10.1023/A:1026203502385. PMID 14618028. 
• Aust G, Sittig D, Becherer L, et al. (2004). "The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases.". Eur. J. Endocrinol. 150 (2): 225–34. doi:10.1530/eje.0.1500225. PMID 14763921. 
• Qiuping Z, Jie X, Youxin J, et al. (2005). "Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia.". Oncogene 24 (4): 573–84. doi:10.1038/sj.onc.1208184. PMID 15580304. 
• Howard OM, Dong HF, Su SB, et al. (2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.". Blood 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1895027. 
• Steinmetz OM, Panzer U, Kneissler U, et al. (2005). "BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection.". Kidney Int. 67 (4): 1616–21. doi:10.1111/j.1523-1755.2005.00244.x. PMID 15780119. 
• Hu C, Xiong J, Zhang L, et al. (2006). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia.". Cell. Mol. Immunol. 1 (4): 280–94. PMID 16225771.