CXCR7

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Atypical chemokine receptor 3
Identifiers
Symbols ACKR3 ; CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159; RDC-1; RDC1
External IDs OMIM610376 MGI109562 HomoloGene22419 IUPHAR: GeneCards: ACKR3 Gene
RNA expression pattern
PBB GE CXCR7 212977 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57007 12778
Ensembl ENSG00000144476 ENSMUSG00000044337
UniProt P25106 P56485
RefSeq (mRNA) NM_001047841 NM_001271607
RefSeq (protein) NP_064707 NP_001258536
Location (UCSC) Chr 2:
237.48 – 237.49 Mb
Chr 1:
90.2 – 90.22 Mb
PubMed search [1] [2]

C-X-C chemokine receptor type 7 (CXCR-7) is a protein that in humans is encoded by the CXCR7 gene.[1][2]

This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.[2]

However, another recent study has provided evidence that ligand binding to CXCR7 activates MAP kinases through Beta-arrestins, and thus has functions beyond ligand sequestration.[3]

References[edit]

  1. ^ Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F (Oct 2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes". J Biol Chem 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333. 
  2. ^ a b "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7". 
  3. ^ *Rajagopal, Sudarshan. et al. (2009). "B-arrestin-but not G protein-mediated signaling by the "decoy" receptor CXCR7.". PNAS 107 (2): 628–632. doi:10.1073/pnas.0912852107. PMC 2818968. PMID 20018651. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.