CYP26A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cytochrome P450, family 26, subfamily A, polypeptide 1
Identifiers
Symbols CYP26A1 ; CP26; CYP26; P450RAI; P450RAI1
External IDs OMIM602239 MGI1096359 HomoloGene37349 ChEMBL: 5141 GeneCards: CYP26A1 Gene
EC number 1.14.-.-
RNA expression pattern
PBB GE CYP26A1 206424 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1592 13082
Ensembl ENSG00000095596 ENSMUSG00000024987
UniProt O43174 O55127
RefSeq (mRNA) NM_000783 NM_007811
RefSeq (protein) NP_000774 NP_031837
Location (UCSC) Chr 10:
94.83 – 94.84 Mb
Chr 19:
37.7 – 37.7 Mb
PubMed search [1] [2]

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.[3]

CYP26A1 is over-expressed in colorectal cancer cells compared to normal colonic epithelium but is of no independent prognostic value in patients with colorectal cancer.[4]

References[edit]

  1. ^ White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M (Sep 1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". J Biol Chem 272 (30): 18538–41. doi:10.1074/jbc.272.30.18538. PMID 9228017. 
  2. ^ White JA, Beckett B, Scherer SW, Herbrick JA, Petkovich M (Jun 1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883. 
  3. ^ a b "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1". 
  4. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776. 

Further reading[edit]