CYP26B1

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Cytochrome P450, family 26, subfamily B, polypeptide 1
Identifiers
Symbols CYP26B1 ; CYP26A2; P450RAI-2; P450RAI2; RHFCA
External IDs OMIM605207 MGI2176159 HomoloGene23179 GeneCards: CYP26B1 Gene
RNA expression pattern
PBB GE CYP26B1 219825 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56603 232174
Ensembl ENSG00000003137 ENSMUSG00000063415
UniProt Q9NR63 Q811W2
RefSeq (mRNA) NM_001277742 NM_001177713
RefSeq (protein) NP_001264671 NP_001171184
Location (UCSC) Chr 2:
72.36 – 72.38 Mb
Chr 6:
84.57 – 84.59 Mb
PubMed search [1] [2]

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.[2]

CYP26B1 has been shown to be over-expressed in colorectal cancer cells compared to normal colonic epithelium. CYP26B1 expression was also independently prognostic in patients with colorectal cancer and strong expression was associated with a poorer outcome.[3]

References[edit]

  1. ^ Nelson DR (Dec 1999). "A second CYP26 P450 in humans and zebrafish: CYP26B1". Arch Biochem Biophys 371 (2): 345–7. doi:10.1006/abbi.1999.1438. PMID 10545224. 
  2. ^ a b "Entrez Gene: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1". 
  3. ^ Brown, Gordon; Beatriz Cash, Daniela Blihoghe, Petronella Johansson, Ayham Alnabulsi, Graeme Murray (07/03/2014). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776. 

Further reading[edit]